Ranbezolid
Ranbezolid is an oxazolidinone antibiotic that is currently under development. It is a synthetic antibacterial agent that has demonstrated significant in vitro and in vivo activity against a broad spectrum of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).
Mechanism of Action[edit | edit source]
Ranbezolid inhibits protein synthesis in bacteria by binding to the ribosome and blocking the formation of a functional 70S-initiation complex. This is a critical step in the bacterial translation process and is therefore a point of attack for several antibiotic classes.
Pharmacokinetics[edit | edit source]
Ranbezolid is well absorbed after oral administration and has a bioavailability of approximately 90%. It is extensively distributed to tissues and fluids, including lung tissue and cerebrospinal fluid. The drug is primarily metabolized by the liver and excreted in the urine and feces.
Clinical Trials[edit | edit source]
Ranbezolid has undergone Phase 2 clinical trials for the treatment of complicated skin and skin structure infections (cSSSI) caused by Gram-positive bacteria, including MRSA and VRE. The results of these trials have shown that ranbezolid is well tolerated and effective in the treatment of these infections.
Side Effects[edit | edit source]
The most common side effects of ranbezolid include nausea, vomiting, diarrhea, and headache. Less common side effects include dizziness, insomnia, and rash.
See Also[edit | edit source]
- Oxazolidinone
- Antibiotic
- Methicillin-resistant Staphylococcus aureus
- Vancomycin-resistant enterococci
Ranbezolid Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD