SB-431542

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SB-431542 is a chemical compound that acts as a potent and selective inhibitor of the transforming growth factor beta (TGF-β) type I receptor ALK5. It is widely used in biological research to study the role of TGF-β signaling in various cellular processes.

Mechanism of Action

SB-431542 inhibits the TGF-β type I receptor ALK5, which is a key component of the TGF-β signaling pathway. By blocking this receptor, SB-431542 prevents the phosphorylation and activation of Smad2 and Smad3, which are downstream effectors in the TGF-β signaling cascade. This inhibition can affect various cellular processes such as cell proliferation, differentiation, and apoptosis.

Applications in Research

SB-431542 is commonly used in stem cell research to maintain the pluripotency of human embryonic stem cells (hESCs) and to promote the differentiation of induced pluripotent stem cells (iPSCs) into specific cell types. It is also used in cancer research to study the role of TGF-β signaling in tumor progression and metastasis.

Chemical Properties

SB-431542 has the IUPAC name 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide. It has a molecular formula of C22H16N4O3 and a molecular weight of 384.39 g/mol. The compound is characterized by its benzodioxole and pyridine moieties, which contribute to its biological activity.

Safety and Handling

As with many chemical compounds used in research, proper safety protocols should be followed when handling SB-431542. It should be stored in a cool, dry place and handled with appropriate personal protective equipment (PPE) to avoid exposure.

See Also

• Transforming growth factor beta
• ALK5
• Smad2
• Smad3
• Stem cell research
• Cancer research

References

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