STMN3

Ideogram house mouse chromosome 2

STMN3

Stathmin 3 (STMN3) is a protein that in humans is encoded by the STMN3 gene. It is a member of the stathmin family which plays a role in the regulation of microtubule dynamics. STMN3 is primarily expressed in the brain and is involved in neuronal development and function.

Structure

The STMN3 gene is located on chromosome 2 in humans and consists of 11 exons. The protein encoded by this gene contains a stathmin-like domain that interacts with tubulin, a key component of microtubules. STMN3 is phosphorylated by various kinases, which regulates its activity in microtubule destabilization.

Function

STMN3 is known to regulate microtubule dynamics by promoting microtubule depolymerization. This activity is crucial for processes such as cell division, intracellular transport, and neuronal morphogenesis. In the brain, STMN3 is involved in axon guidance, dendritic branching, and synaptic plasticity.

Clinical Significance

Mutations in the STMN3 gene have been associated with neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. Dysregulation of STMN3 expression has also been linked to neurodegenerative diseases like Alzheimer's and Parkinson's.

Interactions

STMN3 interacts with various proteins involved in microtubule dynamics, including tubulin, MAPs, and kinases. These interactions modulate the stability and organization of microtubules in different cellular contexts.