Shroom family member 2

Shroom family member 2 (also known as Shroom2) is a protein that in humans is encoded by the SHROOM2 gene. This protein is a member of the Shroom protein family, which is characterized by a conserved SH3 domain and a semi-conserved PDZ domain.

Function

Shroom2 is involved in the regulation of cell shape and cellular architecture, particularly during embryonic development. It plays a crucial role in neural tube formation and neuronal differentiation. Shroom2 is also implicated in the establishment of cell polarity and actin organization.

Structure

The Shroom2 protein consists of several domains, including an SH3 domain at the N-terminus and a PDZ domain at the C-terminus. The SH3 domain is involved in protein-protein interactions, while the PDZ domain is responsible for binding to the cytoskeleton.

Clinical significance

Mutations in the SHROOM2 gene have been associated with X-linked intellectual disability. Studies have also suggested a potential role for Shroom2 in the progression of certain types of cancer, including breast cancer and colorectal cancer.

See also

• Shroom family
• SH3 domain
• PDZ domain
• X-linked intellectual disability
• Breast cancer
• Colorectal cancer

References

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