Solute carrier organic anion transporter family member 2A1

Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a protein that in humans is encoded by the SLCO2A1 gene. This protein is a member of the solute carrier family, specifically the organic anion transporting polypeptides. These proteins are involved in the transport of various compounds across the cell membrane.

Function

The SLCO2A1 gene encodes a protein that is a member of the solute carrier family. This family of proteins is responsible for the transport of a wide variety of substrates across the cell membrane. The protein encoded by SLCO2A1 is specifically involved in the transport of organic anions. These organic anions can include a variety of compounds, such as bile acids, thyroid hormones, and conjugated steroids.

Clinical significance

Mutations in the SLCO2A1 gene have been associated with several medical conditions. These include primary hypertrophic osteoarthropathy, a rare genetic disorder characterized by digital clubbing, periostosis, and pachydermia, and chronic nonspecific multiple ulcers of small intestine, a rare disorder characterized by multiple small intestinal ulcers of nonspecific origin.

See also

• Solute carrier family
• Organic anion transporting polypeptide
• Primary hypertrophic osteoarthropathy
• Chronic nonspecific multiple ulcers of small intestine

References

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