TFDP1

Protein TFDP1 PDB 2aze

TFDP1

TFDP1 is a gene that encodes a member of the basic helix-loop-helix (bHLH) transcription factor family. This gene plays a crucial role in regulating gene expression and is involved in various cellular processes such as cell proliferation, differentiation, and apoptosis.

Function

TFDP1 functions as a transcription factor by forming a heterodimer with E2F transcription factors. This complex binds to specific DNA sequences known as E2F-binding sites and regulates the expression of genes involved in cell cycle progression and DNA replication.

Role in Cell Cycle Regulation

TFDP1-E2F complexes play a central role in controlling the cell cycle by activating the transcription of genes required for cell proliferation. Dysregulation of TFDP1 expression can lead to uncontrolled cell growth and contribute to the development of cancer.

Clinical Significance

Mutations in the TFDP1 gene have been associated with various cancers, including breast cancer and lung cancer. Understanding the role of TFDP1 in cancer development may provide insights into potential therapeutic targets for cancer treatment.

Interactions

TFDP1 interacts with a variety of proteins involved in cell cycle regulation, DNA repair, and apoptosis. These interactions are essential for coordinating cellular processes and maintaining genomic stability.