TICAM2

Ideogram human chromosome 5

TICAM2

TICAM2 (TIR domain-containing adapter molecule 2) is a protein-coding gene that plays a crucial role in the innate immune response. It is also known as TRAM (TRIF-related adapter molecule) and is involved in the signaling pathways triggered by Toll-like receptors (TLRs) and the activation of the immune system.

Function

TICAM2 functions as an adapter molecule that bridges the interaction between TLR4 and TRIF, leading to the activation of downstream signaling cascades that result in the production of pro-inflammatory cytokines and type I interferons. This activation is essential for the host defense against pathogens and the regulation of immune responses.

Structure

The TICAM2 protein contains a Toll/interleukin-1 receptor (TIR) domain, which is responsible for mediating protein-protein interactions with other TIR domain-containing proteins such as TLR4 and TRIF. This interaction is crucial for the initiation of the signaling cascade that leads to the activation of the immune response.

Clinical Significance

Mutations in the TICAM2 gene have been associated with various immune-related disorders, including autoimmune diseases and susceptibility to infections. Understanding the role of TICAM2 in immune regulation may provide insights into the development of novel therapeutic strategies for treating these conditions.