TMEM29

Ideogram human chromosome X

TMEM29

TMEM29 is a protein-coding gene also known as Transmembrane Protein 29. It is located on chromosome 11 in humans. TMEM29 is involved in the regulation of intracellular trafficking and plays a crucial role in maintaining cellular homeostasis.

Function

TMEM29 functions as a transmembrane protein that is primarily localized in the endoplasmic reticulum (ER). It is involved in the transport of proteins within the ER and is essential for proper protein folding and quality control. TMEM29 also interacts with other ER-resident proteins to facilitate the transport of lipids and maintain ER membrane integrity.

Clinical Significance

Mutations in the TMEM29 gene have been associated with certain genetic disorders, including neurodegenerative diseases and metabolic disorders. Dysregulation of TMEM29 expression can lead to ER stress and impaired protein trafficking, which may contribute to the pathogenesis of these diseases.

Research

Research on TMEM29 is ongoing to further elucidate its molecular functions and potential therapeutic implications. Studies are focused on understanding the role of TMEM29 in cellular processes such as autophagy, lipid metabolism, and ER stress response.