Thialbarbital
Thialbarbital is a barbiturate derivative. It has sedative and hypnotic properties, and was used in the mid-20th century for the induction of anesthesia in patients undergoing surgery. Thialbarbital is a short-acting barbiturate, meaning its effects are felt quickly but do not last long. It is not commonly used today due to the development of safer and more effective alternatives.
History[edit | edit source]
Thialbarbital was first synthesized in the 1930s as part of a series of barbiturate derivatives. It was used in clinical practice for several decades, but has largely been replaced by other drugs.
Pharmacology[edit | edit source]
Like other barbiturates, thialbarbital works by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter, meaning it reduces the activity of neurons. By enhancing the action of GABA, thialbarbital induces a state of sedation and relaxation.
Medical uses[edit | edit source]
Thialbarbital was used for the induction of anesthesia in surgical procedures. It was typically administered intravenously, and its effects were felt within a few minutes. The duration of action was relatively short, usually less than an hour.
Side effects[edit | edit source]
Common side effects of thialbarbital include drowsiness, dizziness, and confusion. More serious side effects can include respiratory depression, low blood pressure, and dependence.
See also[edit | edit source]
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