Trimethylsilyldiazomethane
Trimethylsilyldiazomethane (TMSD) is a chemical compound used as a reagent in organic chemistry. It is a colorless liquid that is stable at room temperature and is often used as a safer alternative to diazomethane in various chemical reactions.
Structure and Properties[edit | edit source]
Trimethylsilyldiazomethane is a diazomethane derivative where the methyl group is replaced by a trimethylsilyl group. It has a molecular formula of C4H10N2Si and a molar mass of 114.22 g/mol. The compound is a colorless liquid at room temperature and has a boiling point of 93-95 °C.
Synthesis[edit | edit source]
Trimethylsilyldiazomethane can be synthesized from trimethylsilyl chloride and diazomethane. The reaction is carried out in the presence of a base such as triethylamine.
Applications[edit | edit source]
Trimethylsilyldiazomethane is primarily used as a methylating agent in organic chemistry. It is often used as a safer alternative to diazomethane, which is highly toxic and potentially explosive. TMSD can be used in a variety of reactions, including the methylation of carboxylic acids, phenols, and alcohols.
Safety[edit | edit source]
While trimethylsilyldiazomethane is less hazardous than diazomethane, it is still a potentially dangerous compound. It is flammable and can react violently with strong oxidizing agents. Proper safety precautions should be taken when handling this compound.
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD