Ubiquitin-fold modifier conjugating enzyme 1
Ubiquitin-fold modifier conjugating enzyme 1 (UFC1) is a protein that in humans is encoded by the UFC1 gene. The UFC1 protein is a member of the ubiquitin-conjugating enzyme family and is involved in a variety of cellular processes, including protein degradation, DNA repair, and cell cycle regulation.
Function[edit | edit source]
UFC1 is a enzyme that catalyzes the covalent attachment of ubiquitin-like proteins (UBLs) to target proteins. This process, known as ubiquitination, is a key regulatory mechanism in many cellular processes. UFC1 specifically conjugates the UBL ubiquitin-fold modifier 1 (UFM1) to target proteins.
Structure[edit | edit source]
The UFC1 protein is composed of 107 amino acids and has a molecular weight of approximately 12 kDa. It contains a ubiquitin-conjugating (UBC) domain, which is responsible for its enzymatic activity.
Clinical significance[edit | edit source]
Mutations in the UFC1 gene have been associated with a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In particular, overexpression of UFC1 has been observed in several types of cancer, suggesting a potential role in tumorigenesis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- UFC1 at the National Center for Biotechnology Information
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