Vladimir Prelog

Spomenik HAZU Mirogoj srpanj 2007

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Vladimir Prelog (23 July 1906 – 7 January 1998) was a Yugoslav and Swiss organic chemist, renowned for his research in the field of organic chemistry and for being awarded the Nobel Prize in Chemistry in 1975. His work significantly contributed to the understanding of the stereochemistry of organic molecules and reactions. Prelog's contributions to chemistry include the development of the CIP (Cahn-Ingold-Prelog) priority rules for naming chiral molecules.

Early Life and Education

Vladimir Prelog was born in Sarajevo, which was then part of the Austro-Hungarian Empire (now in Bosnia and Herzegovina). He pursued his higher education in chemistry at the Czech Technical University in Prague, where he received his doctorate in 1929. His early work was influenced by his studies and research in Prague, setting the foundation for his lifelong contributions to organic chemistry.

Career and Research

After completing his education, Prelog began his academic career at the University of Zagreb. In 1941, amidst the turmoil of World War II, he moved to Switzerland, where he joined the Federal Institute of Technology in Zurich. It was here that Prelog made significant strides in his research, focusing on the stereochemistry of organic compounds.

One of Prelog's most notable contributions to chemistry was the development of the CIP system, alongside Robert S. Cahn and Christopher Kelk Ingold. This system provided a standardized method for naming chiral molecules based on their spatial configuration, which was a significant advancement in the field of stereochemistry.

Prelog's research also extended to the synthesis and study of natural products, including antibiotics. His work in this area not only contributed to the understanding of the chemical structure of these compounds but also to the development of methods for their synthesis.

Nobel Prize

In 1975, Vladimir Prelog was awarded the Nobel Prize in Chemistry for his research into the stereochemistry of organic molecules and reactions. His award was shared with John Cornforth, who was recognized for his work on the stereochemistry of enzyme-catalyzed reactions. Prelog's Nobel Prize was a testament to the impact of his contributions to the field of organic chemistry, particularly in the understanding and application of stereochemistry.

Legacy

Vladimir Prelog's legacy in the field of chemistry is marked by his contributions to the understanding of the stereochemistry of organic compounds. His work has had a lasting impact on the field, influencing research and teaching in organic chemistry for decades. The CIP system remains a fundamental aspect of chemical nomenclature, used by chemists worldwide.

Prelog's dedication to research and education was also evident in his role as a mentor to young scientists. Throughout his career, he was known for his commitment to fostering the next generation of chemists, contributing to the growth and development of the field.

Death and Honors

Vladimir Prelog passed away on 7 January 1998 in Zurich, Switzerland. His death marked the loss of one of the most influential chemists of the 20th century. Prelog's contributions to chemistry have been recognized through numerous awards and honors, in addition to the Nobel Prize. His legacy continues to inspire chemists and researchers in the field of organic chemistry.