ZBTB7B

ZBTB7B (also known as ThPok or cKrox) is a gene that encodes a transcription factor in the human body. This gene is a member of the POK (POZ and Krüppel) family of transcriptional repressors.

Function

The ZBTB7B gene plays a crucial role in the immune system, particularly in the development and function of T cells. It is involved in the differentiation of CD4+ T cells, which are a type of white blood cell that fights off infections. The gene is also involved in the regulation of cell cycle progression and apoptosis, or programmed cell death.

Structure

The ZBTB7B gene is located on the short (p) arm of chromosome 19 at position 13.3. The gene spans approximately 20 kilobases and consists of four exons. The encoded protein contains a BTB/POZ domain, which is involved in protein-protein interactions, and a Krüppel-type zinc finger domain, which is involved in DNA binding.

Clinical significance

Mutations in the ZBTB7B gene have been associated with a variety of diseases. For example, a loss of function mutation in this gene has been linked to autoimmune diseases such as rheumatoid arthritis and lupus. Additionally, overexpression of the ZBTB7B gene has been observed in certain types of cancer, including breast cancer and prostate cancer.

Research

Research on the ZBTB7B gene is ongoing, with scientists seeking to better understand its role in the immune system and its potential as a target for new treatments for autoimmune diseases and cancer.

See also

• Zinc finger
• Transcription factor
• T cell
• CD4+ T cell
• Autoimmune disease
• Cancer

References

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