ZNF19
ZNF19 or Zinc Finger Protein 19 is a protein that in humans is encoded by the ZNF19 gene. The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2 type zinc fingers.
Function[edit | edit source]
ZNF19 is a transcription factor that can bind DNA, RNA, and proteins. The protein functions as a regulator of transcription and is involved in cellular processes such as cell differentiation, cell growth, wound healing, and apoptosis.
Structure[edit | edit source]
The ZNF19 protein is composed of a KRAB domain and eighteen C2H2 type zinc fingers. The KRAB domain is a protein domain found in a subset of zinc finger proteins. It functions as a transcriptional repressor. The C2H2 type zinc fingers are the classical type of zinc finger and are the most common type of zinc finger found in transcription factors.
Clinical Significance[edit | edit source]
While the exact clinical significance of ZNF19 is not fully understood, it is believed to play a role in various diseases due to its function as a transcription factor. Abnormalities in transcription factors can lead to diseases such as cancer, autoimmune diseases, and developmental disorders.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD