Zymosan

Zymosan

Zymosan

Zymosan is a biological compound derived from the cell walls of yeast that is commonly used in immunology research to stimulate the immune system. It is a complex mixture of polysaccharides and proteins that can activate various immune cells, such as macrophages and neutrophils, leading to the production of cytokines and other immune mediators.

Structure

Zymosan is primarily composed of β-glucans, mannans, and proteins. The β-glucans are recognized by pattern recognition receptors on immune cells, such as the Dectin-1 receptor, triggering a series of signaling events that culminate in the activation of the immune response.

Immunological Effects

Upon recognition by immune cells, zymosan can induce phagocytosis, inflammation, and the production of various cytokines and chemokines. These responses play a crucial role in the host defense against pathogens and in the regulation of the immune system.

Applications

Zymosan is widely used in immunology research to study immune cell activation, inflammation, and host-pathogen interactions. It has been employed in various experimental models to investigate the mechanisms underlying immune responses and to develop potential therapeutic strategies for immune-related disorders.

See also

• Yeast
• Immune system
• Polysaccharide
• Macrophage
• Neutrophil