1-Methylnicotinamide

1-Methylnicotinamide.svg

1-Methylnicotinamide (1-MNA) is a chemical compound that is a derivative of nicotinamide, a form of vitamin B3. It is also known as N-methylnicotinamide or trigonellinamide.

Chemical Structure and Properties

1-Methylnicotinamide has the IUPAC name N-Methylpyridine-3-carboxamide. Its molecular formula is C₇H₈N₂O, and it has a molar mass of 136.15 g/mol. The compound is characterized by a pyridine ring with a carboxamide group at the 3-position and a methyl group attached to the nitrogen atom.

Biological Role

1-Methylnicotinamide is a metabolite of nicotinamide and is involved in various biological processes. It is known to exhibit anti-inflammatory and vasoprotective properties. The compound is also studied for its potential role in cardiovascular diseases and diabetes.

Metabolism

1-Methylnicotinamide is produced in the body through the methylation of nicotinamide by the enzyme nicotinamide N-methyltransferase (NNMT). This process is part of the NAD+ salvage pathway, which is crucial for maintaining cellular energy balance and redox reactions.

Medical Research

Research on 1-Methylnicotinamide has shown its potential therapeutic effects in various conditions. Studies suggest that it may help in reducing inflammation, improving endothelial function, and protecting against oxidative stress. These properties make it a subject of interest in the treatment of cardiovascular diseases, diabetes, and other inflammatory conditions.

See Also

• Nicotinamide
• Nicotinic acid
• NAD+
• Vitamin B3
• Nicotinamide N-methyltransferase

References

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