25N-NBOMe

25N-NBOMe structure 300px

25N-NBOMe, also known as 2C-N-NBOMe, N-(2-methoxybenzyl)-2C-N, or colloquially as "N-Bomb", is a psychedelic drug that belongs to the NBOMe series of substituted phenethylamines. This compound is closely related to 2C-N, a member of the 2C family of psychedelics first synthesized by Alexander Shulgin. 25N-NBOMe acts primarily as a highly potent agonist for the 5-HT2A receptor, leading to its psychedelic effects. Due to its high potency, it is often found on blotter paper similar to the way LSD is distributed, and it has been associated with several cases of overdoses and fatalities, raising significant concerns about its safety.

Chemistry

25N-NBOMe is a derivative of the phenethylamine psychedelic 2C-N, with the addition of a methoxybenzyl (NBOMe) group. This modification significantly increases its affinity for the 5-HT2A receptor, making it much more potent than its parent compound. The chemical structure of 25N-NBOMe consists of a core phenethylamine structure, featuring a benzene ring at one end and a methoxybenzyl group attached to the nitrogen (N) of the ethylamine chain.

Pharmacology

The primary mechanism of action of 25N-NBOMe involves its function as an agonist at the 5-HT2A receptor, a subtype of the serotonin receptor. This action is responsible for its psychedelic effects. The compound has a much higher affinity for this receptor than traditional psychedelics, making it significantly more potent and potentially more hazardous. Its effects can vary widely among individuals, influenced by factors such as dosage, the individual's body chemistry, and the presence of other substances.

Effects

The effects of 25N-NBOMe can be both psychedelic and stimulant-like, including visual and auditory hallucinations, enhanced emotions, euphoria, significant alterations in perception, and increased energy. However, due to its potency, the risk of negative effects, including severe vasoconstriction, seizures, and acute psychosis, is considerably higher than with many other psychedelics. The duration of effects typically ranges from 6 to 10 hours, depending on the dose and individual metabolism.

Risks and Safety

The safety profile of 25N-NBOMe is a significant concern. There have been multiple reported cases of accidental overdoses and deaths attributed to the substance. Its high potency and narrow margin between recreational dose and overdose make it particularly risky, especially when the substance is misidentified as LSD or another less potent psychedelic. Symptoms of overdose may include severe agitation, cardiac toxicity, seizures, and acute psychosis.

Legal Status

As of the writing of this article, 25N-NBOMe is illegal in many countries due to its potential for abuse and the associated health risks. It has been classified as a controlled substance in several jurisdictions, aiming to curb its distribution and use.

Conclusion

25N-NBOMe is a powerful psychedelic with significant risks associated with its use. While it may offer profound alterations in perception and consciousness, the potential for harm and legal consequences makes it a substance of concern within the drug community and among health professionals. Individuals are strongly advised to exercise caution and be fully informed of the legal and health implications before considering its use.

This substance-related article is a stub. You can help WikiMD by expanding it.