4-HO-DET

4-HO-DET.svg

4-HO-DET (4-hydroxy-N,N-diethyltryptamine) is a psychedelic tryptamine derivative. It is closely related to psilocin (4-HO-DMT), the active compound in psilocybin mushrooms, and is known for its psychoactive effects.

Chemical Structure and Properties

4-HO-DET belongs to the class of tryptamines, which are structurally similar to the neurotransmitter serotonin. The chemical structure of 4-HO-DET consists of a tryptamine backbone with a hydroxy group at the 4-position and two ethyl groups attached to the nitrogen atom. Its chemical formula is C14H20N2O.

Pharmacology

4-HO-DET acts primarily as a serotonin receptor agonist, particularly at the 5-HT2A receptor, which is believed to play a significant role in its psychedelic effects. The compound is known to induce alterations in perception, mood, and cognition, similar to other psychedelics like LSD and psilocybin.

Effects

The effects of 4-HO-DET can vary depending on the dose, individual, and setting. Common effects include visual and auditory hallucinations, changes in thought patterns, and an altered sense of time. Users may also experience emotional and spiritual insights. The duration of effects typically lasts between 4 to 6 hours.

History and Use

4-HO-DET was first synthesized by Alexander Shulgin, a renowned chemist known for his work with psychoactive compounds. It is documented in his book TiHKAL (Tryptamines I Have Known and Loved). While not as widely known or used as other psychedelics, 4-HO-DET has been used in both recreational and research settings.

Legal Status

The legal status of 4-HO-DET varies by country. In some places, it is classified as a controlled substance, making its possession, sale, or use illegal. In other regions, it may be unscheduled or fall into a legal gray area.

Safety and Risks

As with other psychedelics, the use of 4-HO-DET carries potential risks, including psychological distress, anxiety, and the possibility of triggering latent mental health issues. It is advised to use such substances in a safe and controlled environment, preferably with a sober sitter present.

See Also

• Psychedelic drug
• Tryptamine
• Psilocin
• Alexander Shulgin
• TiHKAL