5-MeO-AET

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5-MeO-AET

5-MeO-AET (5-Methoxy-alpha-ethyltryptamine) is a psychedelic drug and research chemical belonging to the tryptamine class. This compound is known for its psychoactive properties and is related to both 5-MeO-DMT and AET (alpha-ethyltryptamine). 5-MeO-AET is part of a broader category of substances known as entheogens, which are used to induce altered states of consciousness for spiritual, religious, or psychotherapeutic purposes.

Chemistry[edit | edit source]

5-MeO-AET is a synthetic molecule of the tryptamine family. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 5-MeO-AET is substituted at the R5 position of the indole ring with a methoxy (MeO) group. It also features an ethyl chain at the alpha carbon, a characteristic it shares with its close relative AET.

Pharmacology[edit | edit source]

The pharmacological action of 5-MeO-AET is not well understood, but it is believed to work similarly to other tryptamines, by acting as an agonist at serotonin receptors. Its psychoactive effects are likely due to its action on the 5-HT2A receptor, a common mechanism of action for many psychedelics. However, the specific pharmacodynamics and the full spectrum of its receptor activity remain under-researched.

Effects[edit | edit source]

Users of 5-MeO-AET report a variety of effects that are typical of psychedelic tryptamines, including enhanced visual and auditory perception, altered sense of time, euphoria, introspection, and in some cases, profound mystical or existential experiences. However, the subjective effects of 5-MeO-AET can vary greatly among individuals, and like all psychedelics, its effects can be influenced by factors such as dose, set (the user's mental state), and setting (the environment in which it is used).

Legality[edit | edit source]

The legal status of 5-MeO-AET varies from country to country. In some jurisdictions, it is a controlled substance, which means its manufacture, sale, possession, and use are regulated by law. In other places, it may be legal or exist in a legal gray area due to its status as a research chemical and lack of explicit legal classification.

Safety[edit | edit source]

As with many research chemicals, there is limited scientific data on the safety, toxicity, and long-term health effects of 5-MeO-AET. Its use carries potential risks, including psychological distress and harm to physical health. It is strongly advised to approach this substance with caution, and harm reduction practices should be employed by those choosing to use it.


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Contributors: Prab R. Tumpati, MD