ARID1A
ARID1A is a gene that encodes a protein involved in chromatin remodeling, a critical process for the regulation of gene expression. The ARID1A protein is a component of the SWI/SNF complex, which is responsible for the rearrangement of chromatin structure. Mutations in the ARID1A gene have been associated with a variety of cancers, including ovarian cancer, endometrial cancer, and gastric cancer.
Function[edit | edit source]
The ARID1A gene encodes a protein that is part of the SWI/SNF complex. This complex is involved in chromatin remodeling, which is a process that alters the structure of chromatin to allow or prevent the transcription of genes. The ARID1A protein specifically is thought to regulate the binding of the SWI/SNF complex to chromatin.
Clinical significance[edit | edit source]
Mutations in the ARID1A gene have been implicated in a variety of cancers. These mutations often result in a loss of function of the ARID1A protein, which can lead to unregulated gene expression and the development of cancer.
Ovarian cancer[edit | edit source]
ARID1A mutations are particularly common in clear cell carcinoma of the ovary and endometrioid carcinoma of the ovary. These mutations are often associated with a poor prognosis.
Endometrial cancer[edit | edit source]
ARID1A mutations have also been identified in endometrial cancer. These mutations are often associated with a more aggressive form of the disease.
Gastric cancer[edit | edit source]
In gastric cancer, ARID1A mutations are often associated with a poor prognosis. These mutations are particularly common in gastric adenocarcinoma.
See also[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD