Alentemol

alentemol.svg

Alentemol is a pharmaceutical drug used primarily for the treatment of hypertension and certain types of cardiac arrhythmias. It belongs to the class of beta-blockers, which work by blocking the effects of the hormone epinephrine, also known as adrenaline. This action helps to slow down the heart rate and reduce blood pressure.

Mechanism of Action

Alentemol functions by inhibiting the beta-adrenergic receptors in the heart and blood vessels. By blocking these receptors, it prevents the usual binding of epinephrine and norepinephrine, leading to a decrease in heart rate, cardiac output, and the release of renin from the kidneys. This results in lowered blood pressure and reduced strain on the heart.

Indications

Alentemol is indicated for:

• Hypertension
• Angina pectoris
• Cardiac arrhythmias
• Myocardial infarction (post-heart attack management)
• Heart failure (in certain cases)

Side Effects

Common side effects of Alentemol include:

• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)
• Fatigue
• Dizziness
• Cold extremities
• Gastrointestinal disturbances

Serious side effects may include:

• Bronchospasm (especially in patients with asthma)
• Heart block
• Heart failure exacerbation

Contraindications

Alentemol should not be used in patients with:

• Severe bradycardia
• Heart block greater than first degree
• Cardiogenic shock
• Severe asthma or chronic obstructive pulmonary disease (COPD)

Dosage and Administration

The dosage of Alentemol varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally, but the exact dosage should be determined by a healthcare provider.

Pharmacokinetics

Alentemol is well-absorbed from the gastrointestinal tract and undergoes hepatic metabolism. It has a half-life of approximately 6-8 hours, allowing for once or twice daily dosing. The drug is excreted primarily via the kidneys.

History

Alentemol was first developed in the late 20th century as part of the effort to create more selective beta-blockers with fewer side effects compared to earlier drugs in the same class.

See Also

• Beta-blocker
• Hypertension
• Cardiac arrhythmia
• Heart failure

External Links

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