B cell scaffold protein with ankyrin repeats 1
B cell scaffold protein with ankyrin repeats 1 (also known as BANK1) is a protein that in humans is encoded by the BANK1 gene. This protein plays a crucial role in the immune system, specifically in the function of B cells.
Function[edit | edit source]
BANK1 is a scaffold protein that regulates B cell receptor-mediated signal transduction, which is essential for the development and function of B cells. It is involved in the activation of phospholipase C gamma 2 and the calcium signaling pathway, which are critical for B cell activation and function.
Structure[edit | edit source]
The BANK1 protein contains several ankyrin repeats, which are 33-residue motifs in proteins that mediate protein-protein interactions. It also contains a coiled-coil domain, which is involved in protein dimerization and other interactions.
Clinical significance[edit | edit source]
Mutations in the BANK1 gene have been associated with systemic lupus erythematosus, a chronic autoimmune disease that can affect various parts of the body, including the skin, joints, kidneys, and brain.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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