CNQX

CNQX.svg

CNQX (6-Cyano-7-nitroquinoxaline-2,3-dione) is a chemical compound that is widely used in neuroscience research. It acts as an antagonist of the AMPA and kainate receptors, which are types of ionotropic glutamate receptors. By blocking these receptors, CNQX inhibits the excitatory neurotransmission mediated by glutamate, the primary excitatory neurotransmitter in the central nervous system.

Mechanism of Action

CNQX binds to the AMPA and kainate receptors, preventing the binding of glutamate. This inhibition reduces the influx of calcium and sodium ions into the neurons, thereby decreasing neuronal excitability. This property makes CNQX a valuable tool for studying the role of excitatory neurotransmission in various physiological and pathological processes.

Applications in Research

CNQX is commonly used in electrophysiology experiments to study the properties of synaptic transmission and plasticity. It is also employed in neuropharmacology to investigate the effects of excitatory neurotransmission on neural circuits and behavior. Additionally, CNQX has been used in studies of neurodegenerative diseases and epilepsy, where excessive excitatory neurotransmission is a contributing factor.

Safety and Handling

As with many chemical compounds used in research, proper safety protocols should be followed when handling CNQX. It should be stored in a cool, dry place and handled with appropriate personal protective equipment to avoid inhalation, ingestion, or skin contact.

See Also

• AMPA receptor
• Kainate receptor
• Glutamate
• Neuroscience
• Neuropharmacology

References

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