Cinamolol

Cinamolol.svg

Cinamolol is a beta-adrenergic antagonist (beta-blocker) used in the treatment of various cardiovascular conditions. Beta-blockers are a class of medications that reduce the workload on the heart and help it to beat more regularly by blocking the effects of epinephrine (adrenaline).

Pharmacology

Cinamolol works by blocking the beta-adrenergic receptors in the heart, which are part of the sympathetic nervous system. This action decreases the heart rate, the force of heart contractions, and the amount of oxygen the heart needs. It is particularly useful in managing conditions such as hypertension, angina pectoris, and certain types of arrhythmias.

Medical Uses

Cinamolol is primarily prescribed for:

• Hypertension: By lowering blood pressure, cinamolol helps prevent strokes, heart attacks, and kidney problems.
• Angina pectoris: It reduces the frequency and severity of chest pain by decreasing the heart's demand for oxygen.
• Arrhythmias: It helps in maintaining a regular heart rhythm.

Side Effects

Common side effects of cinamolol include:

• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)
• Fatigue
• Dizziness
• Cold extremities

Less common but more serious side effects can include:

• Bronchospasm in patients with asthma
• Heart failure in patients with pre-existing heart conditions
• Depression and other mood changes

Contraindications

Cinamolol should not be used in patients with:

• Severe bradycardia
• Asthma or other severe pulmonary diseases
• Cardiogenic shock
• Heart block (second or third degree)

Mechanism of Action

Cinamolol binds to the beta-1 adrenergic receptors in the heart, inhibiting the action of catecholamines like epinephrine and norepinephrine. This leads to a decrease in cyclic AMP levels, resulting in reduced calcium influx into the heart cells, thereby decreasing heart rate and contractility.

History

Cinamolol was developed in the late 20th century as part of the ongoing research into beta-blockers. It was designed to offer a more selective action on the heart with fewer side effects compared to earlier beta-blockers.

See Also

• Beta-blocker
• Hypertension
• Angina pectoris
• Arrhythmia
• Epinephrine
• Sympathetic nervous system

External Links

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