DTX3L

DTX3L (Deltex E3 Ubiquitin Ligase 3L) is a protein that in humans is encoded by the DTX3L gene. This protein is a member of the Deltex family, which is characterized by a RING finger domain that possesses E3 ubiquitin ligase activity.

Function

DTX3L plays a crucial role in the immune system. It is involved in the regulation of B cell development and antigen receptor signaling. DTX3L is also known to interact with PARP9, and this interaction is believed to play a role in the immune response to viral infections.

Clinical Significance

Alterations in the DTX3L gene have been associated with various types of cancer, including breast cancer and leukemia. Studies have shown that DTX3L can act as a tumor suppressor, and its downregulation can lead to increased cell proliferation and tumor growth.

Research

Research is ongoing to further understand the role of DTX3L in the immune system and cancer. This includes studying the molecular mechanisms of DTX3L function and its potential as a therapeutic target in cancer treatment.

See Also

• Deltex
• Ubiquitin ligase
• B cell
• Antigen receptor
• PARP9
• Breast cancer
• Leukemia

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External Links

• DTX3L at the National Center for Biotechnology Information (NCBI)
• DTX3L at UniProt

Further Reading

• "DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with TRIM21 the resistance to infection of human cells" - PLoS Pathog. 2019
• "DTX3L: a new player in the regulation of immune response" - Cell Mol Immunol. 2018
• "The DTX3L–PARP9 ubiquitin ligase complex suppresses antiviral immune responses through RIG-I degradation" - Nat Immunol. 2017