Diarylpyrimidines
Diarylpyrimidines (DAPYs) are a class of antiretroviral drugs used in the treatment of HIV/AIDS. They are non-nucleoside reverse transcriptase inhibitors (NNRTIs) that bind to the reverse transcriptase enzyme, preventing the conversion of RNA into DNA, a crucial step in the replication of the HIV virus.
History[edit | edit source]
The development of diarylpyrimidines began in the late 1990s, with the aim of overcoming the limitations of the first-generation NNRTIs. The first DAPY to be approved for clinical use was etravirine (Intelence), in 2008.
Mechanism of Action[edit | edit source]
Diarylpyrimidines work by binding to the reverse transcriptase enzyme in a different way than other NNRTIs. This unique binding method allows them to retain their effectiveness against HIV strains that have developed resistance to other NNRTIs.
Clinical Use[edit | edit source]
Diarylpyrimidines are used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS. They are particularly useful in cases where the virus has developed resistance to other NNRTIs.
Side Effects[edit | edit source]
Common side effects of diarylpyrimidines include rash, nausea, and fatigue. More serious side effects can include liver damage and severe skin reactions.
Research[edit | edit source]
Research is ongoing into the development of new diarylpyrimidines with improved effectiveness and fewer side effects.
See Also[edit | edit source]
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