Eomesodermin
Eomesodermin (also known as Eomes) is a T-box transcription factor that plays a crucial role in the development and differentiation of various cell types during embryogenesis. It is encoded by the Eomes gene in humans.
Function[edit | edit source]
Eomesodermin is primarily involved in the formation of mesoderm and endoderm during early embryonic development. It is also essential for the differentiation of CD8+ T cells and natural killer cells, which are critical components of the immune system.
Structure[edit | edit source]
The Eomes gene is located on the long (q) arm of chromosome 3 at position 21.3. The protein encoded by this gene belongs to the T-box family of transcription factors, characterized by a DNA-binding domain known as the T-box.
Role in Disease[edit | edit source]
Mutations in the Eomes gene have been associated with various diseases. For example, a lack of Eomesodermin has been linked to congenital heart defects, neural tube defects, and immune system disorders.
Research[edit | edit source]
Research on Eomesodermin is ongoing, with studies focusing on its role in immune response, embryonic development, and disease pathogenesis. Understanding the function of Eomesodermin could lead to new treatments for a variety of diseases.
See Also[edit | edit source]
- T-box
- Transcription factor
- Embryogenesis
- CD8+ T cells
- Natural killer cells
- Immune system
- Chromosome 3
- Congenital heart defects
- Neural tube defects
- Immune system disorders
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD