Epimestrol
Epimestrol is a synthetic estrogen that belongs to the class of steroidal estrogens. It is primarily used in hormone replacement therapy and for the treatment of menopausal symptoms.
Chemical Structure and Properties[edit | edit source]
Epimestrol is a derivative of estradiol, one of the primary female sex hormones. Its chemical structure is characterized by the presence of a steroid nucleus with specific modifications that enhance its estrogenic activity.
Mechanism of Action[edit | edit source]
Epimestrol functions by binding to estrogen receptors in various tissues, including the reproductive system, bone, and cardiovascular system. This binding activates the receptors, leading to the transcription of estrogen-responsive genes and subsequent physiological effects.
Medical Uses[edit | edit source]
Epimestrol is used in the management of:
- Menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis.
- Hormone replacement therapy in postmenopausal women.
- Certain cases of hypogonadism in women.
Side Effects[edit | edit source]
Like other estrogens, epimestrol can cause a range of side effects, including:
- Nausea
- Breast tenderness
- Headaches
- Increased risk of thromboembolic events
- Potential increased risk of breast cancer with long-term use
Contraindications[edit | edit source]
Epimestrol should not be used in individuals with:
- Known or suspected breast cancer
- Active or history of thromboembolic disorders
- Liver disease
- Known hypersensitivity to the drug
Pharmacokinetics[edit | edit source]
Epimestrol is administered orally and is well-absorbed from the gastrointestinal tract. It undergoes extensive first-pass metabolism in the liver, and its metabolites are excreted primarily in the urine.
History[edit | edit source]
Epimestrol was developed in the mid-20th century as part of efforts to create synthetic estrogens with improved efficacy and safety profiles compared to natural estrogens like estradiol.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD