Guanoxan

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Guanoxan is a pharmaceutical drug that was primarily used as an antihypertensive agent. It belongs to the class of guanidine derivatives and functions by inhibiting the release of norepinephrine from sympathetic nerve endings, thereby reducing blood pressure.

Mechanism of Action

Guanoxan works by blocking the release of norepinephrine, a neurotransmitter involved in the regulation of blood pressure. By inhibiting norepinephrine, guanoxan reduces the sympathetic tone, leading to vasodilation and a subsequent decrease in blood pressure. This mechanism is similar to that of other antihypertensive agents like guanethidine.

Clinical Use

Guanoxan was used in the treatment of hypertension (high blood pressure). It was particularly useful in patients who did not respond adequately to other antihypertensive medications. However, due to the development of newer and more effective antihypertensive drugs with fewer side effects, the use of guanoxan has declined.

Side Effects

The use of guanoxan can lead to several side effects, including:

• Orthostatic hypotension (a sudden drop in blood pressure upon standing)
• Dizziness
• Fatigue
• Nausea
• Diarrhea

History

Guanoxan was developed in the mid-20th century as part of the search for effective antihypertensive agents. It was one of several drugs that emerged during this period, including reserpine and methyldopa. Despite its initial promise, guanoxan was eventually overshadowed by newer medications with better efficacy and safety profiles.

See Also

• Antihypertensive
• Guanidine
• Norepinephrine
• Hypertension
• Guanethidine
• Reserpine
• Methyldopa

External Links

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