HLA-DOA

HLA-DOA is a protein that in humans is encoded by the HLA-DOA gene. It is a part of the Major Histocompatibility Complex (MHC) class II molecules, which are involved in the immune system's ability to recognize foreign substances.

Function

HLA-DOA is an alpha chain of the HLA-DO molecule. It forms a heterodimer with the HLA-DOB beta chain. The HLA-DO molecule is a non-classical MHC class II molecule, meaning it does not directly present antigens, but instead modulates the peptide loading of other MHC class II molecules.

Structure

The HLA-DOA gene is located on the short arm of chromosome 6 (6p21.3). The protein encoded by this gene is a type I transmembrane protein. It has a similar structure to other MHC class II molecules, with two extracellular domains, a transmembrane domain, and a cytoplasmic tail.

Role in Disease

Alterations in the HLA-DOA gene have been associated with various autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. Further research is needed to fully understand the role of HLA-DOA in these diseases.

See Also

• Major Histocompatibility Complex
• HLA-DOB
• Autoimmune diseases

References

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