Homoserine
Homoserine is a non-proteinogenic amino acid with the chemical formula C4H9NO3. It is an intermediate in the biosynthesis of methionine, threonine, and isoleucine.
Structure and Properties[edit | edit source]
Homoserine is structurally similar to the amino acid serine, but it has an additional methylene group. It is classified as a hydroxy acid due to the presence of a hydroxyl group (-OH) attached to the carbon chain. The compound exists in two enantiomeric forms, D-homoserine and L-homoserine, with L-homoserine being the biologically active form.
Biosynthesis[edit | edit source]
Homoserine is synthesized from aspartic acid via a series of enzymatic reactions. The pathway begins with the phosphorylation of aspartic acid to form aspartyl-phosphate, which is then reduced to form aspartate-semialdehyde. This intermediate is subsequently converted to homoserine by the enzyme homoserine dehydrogenase.
Role in Metabolism[edit | edit source]
Homoserine serves as a precursor in the biosynthetic pathways of several essential amino acids:
- Methionine: Homoserine is converted to O-phosphohomoserine, which is then transformed into homocysteine and subsequently methionine.
- Threonine: Homoserine is phosphorylated to form O-phosphohomoserine, which is then converted to threonine by threonine synthase.
- Isoleucine: Homoserine is involved in the biosynthesis of isoleucine through a series of reactions that also involve threonine.
Industrial and Biotechnological Applications[edit | edit source]
Homoserine and its derivatives are used in various industrial and biotechnological applications. It is a key intermediate in the production of amino acids and other compounds through microbial fermentation processes. Additionally, homoserine can be used as a building block in the synthesis of pharmaceuticals and other bioactive molecules.
Related Pages[edit | edit source]
Categories[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD