Indatraline

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Indatraline is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that was originally developed for the treatment of depression and other mood disorders. It is known for its ability to inhibit the reuptake of the three major monoamine neurotransmitters: serotonin, norepinephrine, and dopamine.

Pharmacology

Indatraline functions by blocking the reuptake of serotonin, norepinephrine, and dopamine, thereby increasing the levels of these neurotransmitters in the synaptic cleft and enhancing their activity in the central nervous system. This mechanism of action is similar to that of other SNDRIs, such as cocaine and methylphenidate, but indatraline is not commonly used due to its potential for abuse and side effects.

Chemical Structure

The chemical structure of indatraline is characterized by a tetrahydronaphthalene core with a dichlorophenyl group and a dipropylamine side chain. The IUPAC name for indatraline is (1R,2S)-2-(3,4-dichlorophenyl)-1-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-1-amine.

Clinical Use

Indatraline was initially investigated for its potential use in treating depression and other mood disorders. However, due to its potent effects on the reuptake of multiple neurotransmitters and the associated risk of side effects, it has not been widely adopted in clinical practice. Research into its use has largely been overshadowed by the development of other antidepressants with more favorable safety profiles.

Side Effects

The side effects of indatraline are similar to those of other SNDRIs and can include insomnia, anxiety, nausea, and increased heart rate. Due to its potent action on multiple neurotransmitter systems, there is also a risk of serotonin syndrome and other serious adverse effects.

Research

Despite its limited clinical use, indatraline continues to be of interest in research settings. Studies have explored its potential applications in treating substance use disorders and its effects on neurotransmitter systems.

See Also

• Serotonin-norepinephrine-dopamine reuptake inhibitor
• Monoamine neurotransmitter
• Depression
• Serotonin
• Norepinephrine
• Dopamine

References

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