JWH-081

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JWH-081 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist at both the CB1 and CB2 cannabinoid receptors. JWH-081 was first synthesized by John W. Huffman and his team at Clemson University.

Chemical Structure

JWH-081 has the chemical formula C₂₄H₂₃NO and a molecular weight of 341.45 g/mol. The structure consists of a naphthalene ring attached to an indole core with a pentyl chain at the 1-position of the indole.

Pharmacology

JWH-081 is known to bind to the CB1 and CB2 receptors, which are part of the endocannabinoid system. These receptors are involved in various physiological processes including pain, appetite, mood, and memory. The binding affinity of JWH-081 to these receptors is similar to that of THC, the primary psychoactive component of cannabis.

Legal Status

The legal status of JWH-081 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. For example, in the United States, it is listed as a Schedule I substance under the Controlled Substances Act.

Safety and Toxicity

The safety profile of JWH-081 is not well-documented. However, synthetic cannabinoids in general have been associated with adverse effects such as tachycardia, hypertension, hallucinations, and seizures. Long-term use may lead to addiction and other health issues.

See Also

• Synthetic cannabinoids
• John W. Huffman
• CB1 receptor
• CB2 receptor
• Cannabinoid receptor

References

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