JWH-250

JWH-250

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JWH-250 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist for the cannabinoid receptors, with a preference for the CB1 receptor.

Chemical Structure and Properties

JWH-250 is chemically classified as a naphthoylindole. Its full chemical name is 2-(2-Methoxyphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone. The structure consists of a naphthalene ring system linked to an indole core, with a methoxyphenyl group attached to the ethanone chain.

Pharmacology

JWH-250 acts as a potent agonist for the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system. The CB1 receptor is primarily found in the central nervous system, while the CB2 receptor is more common in the immune system and peripheral tissues. JWH-250 has a higher affinity for the CB1 receptor, which is associated with its psychoactive effects.

Legal Status

JWH-250 is classified as a Schedule I controlled substance in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use. In the United Kingdom, it is classified as a Class B drug. Other countries have similar regulations, reflecting concerns about its potential for abuse and lack of medical applications.

Usage and Effects

JWH-250 is often used in synthetic cannabis products, which are marketed as legal alternatives to cannabis. These products are typically sold under various brand names and are often labeled as "not for human consumption" to circumvent drug laws. The effects of JWH-250 are similar to those of THC, the primary psychoactive component of cannabis, and can include euphoria, relaxation, and altered perception. However, the use of synthetic cannabinoids like JWH-250 can also lead to severe adverse effects, including anxiety, paranoia, and hallucinations.

Health Risks

The use of JWH-250 and other synthetic cannabinoids has been associated with a range of adverse health effects. These can include tachycardia, hypertension, nausea, vomiting, and seizures. There have also been reports of acute kidney injury and cardiovascular complications associated with the use of synthetic cannabinoids.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• JWH-073

References

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