KCNN4

KCNN4 (also known as Intermediate conductance calcium-activated potassium channel protein 4) is a protein that in humans is encoded by the KCNN4 gene. KCNN4 is a member of the potassium channel family of proteins, which play a crucial role in the physiology of many different cell types.

Function

KCNN4 is a calcium-activated potassium channel that contributes to the regulation of cell membrane potential and calcium signaling in various types of cells. It is activated by an increase in intracellular calcium concentration, which can occur as a result of signal transduction pathways or changes in the electrochemical gradient across the cell membrane.

Clinical significance

Mutations in the KCNN4 gene have been associated with various medical conditions. For example, they have been implicated in the development of hereditary xerocytosis, a rare genetic disorder characterized by dehydration of red blood cells. In addition, KCNN4 has been suggested to play a role in the progression of certain types of cancer, including colorectal cancer and breast cancer.

Research

Research into the function and potential therapeutic applications of KCNN4 is ongoing. For example, KCNN4 inhibitors are being investigated for their potential use in the treatment of sickle cell disease and other conditions characterized by abnormal red blood cell dehydration.

See also

• Potassium channel
• Calcium-activated potassium channel
• Hereditary xerocytosis
• Signal transduction

References

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