Loxoprofen
Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its analgesic and anti-inflammatory properties. It is widely prescribed for the treatment of pain and inflammation associated with various conditions such as arthritis, musculoskeletal disorders, and postoperative pain.
Pharmacology[edit | edit source]
Loxoprofen works by inhibiting the synthesis of prostaglandins, which are compounds involved in the mediation of inflammation and pain. It is a prodrug, meaning it is metabolized in the body to its active form, trans-OH loxoprofen, which exerts the therapeutic effects.
Mechanism of Action[edit | edit source]
The primary mechanism of action of loxoprofen involves the inhibition of the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. By blocking these enzymes, loxoprofen reduces the production of prostaglandins, thereby decreasing inflammation and pain.
Clinical Uses[edit | edit source]
Loxoprofen is indicated for the management of:
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute musculoskeletal pain
- Postoperative pain
Administration and Dosage[edit | edit source]
Loxoprofen is available in various forms, including oral tablets and topical formulations. The typical oral dosage for adults is 60 mg taken three times a day. The dosage may be adjusted based on the patient's response and the severity of the condition.
Side Effects[edit | edit source]
Common side effects of loxoprofen include:
- Gastrointestinal disturbances such as nausea, vomiting, and dyspepsia
- Headache
- Dizziness
- Rash
Serious side effects, although rare, may include gastrointestinal bleeding, peptic ulcer, and renal impairment.
Contraindications[edit | edit source]
Loxoprofen is contraindicated in patients with:
- Known hypersensitivity to loxoprofen or other NSAIDs
- History of asthma attacks, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer disease
- Severe hepatic or renal impairment
Precautions[edit | edit source]
Caution is advised when prescribing loxoprofen to patients with:
Interactions[edit | edit source]
Loxoprofen may interact with other medications, including:
- Anticoagulants such as warfarin
- Other NSAIDs
- Corticosteroids
- Diuretics
- ACE inhibitors
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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