Norepinephrine–dopamine disinhibitor

Agomelatine

Norepinephrine–dopamine disinhibitor

A norepinephrine–dopamine disinhibitor (NDDI) is a type of drug that primarily functions by inhibiting the action of certain neurotransmitters, specifically norepinephrine and dopamine. These drugs are typically used in the treatment of various psychiatric disorders, including depression, anxiety disorders, and attention deficit hyperactivity disorder (ADHD).

Mechanism of Action

Norepinephrine–dopamine disinhibitors work by blocking the reuptake of norepinephrine and dopamine, which increases the levels of these neurotransmitters in the synaptic cleft. This action enhances neurotransmission and can improve mood, attention, and overall cognitive function. The increased availability of norepinephrine and dopamine can help alleviate symptoms of depression and anxiety, as well as improve focus and attention in individuals with ADHD.

Clinical Uses

NDDIs are primarily prescribed for the treatment of:

• Major depressive disorder
• Generalized anxiety disorder
• Attention deficit hyperactivity disorder
• Bipolar disorder (as an adjunctive treatment)

Side Effects

Common side effects of norepinephrine–dopamine disinhibitors may include:

• Insomnia
• Nausea
• Dry mouth
• Increased heart rate
• Anxiety

Less common but more serious side effects can include:

• Hypertension
• Cardiac arrhythmia
• Seizures

Examples of Norepinephrine–Dopamine Disinhibitors

Some well-known NDDIs include:

• Bupropion
• Methylphenidate
• Atomoxetine

See Also

• Selective serotonin reuptake inhibitor
• Serotonin–norepinephrine reuptake inhibitor
• Monoamine oxidase inhibitor
• Tricyclic antidepressant

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