PD-128,907

PD-128,907 Structure

PD-128,907 is a synthetic compound that acts as a selective agonist for the D2-like dopamine receptors. It is primarily used in scientific research to study the role of these receptors in various physiological and pathological processes.

Chemical Properties

PD-128,907 is a member of the benzamide class of compounds. Its chemical structure allows it to selectively bind to D2-like dopamine receptors, which include the D2, D3, and D4 subtypes. This selectivity makes it a valuable tool for distinguishing the functions of these receptors in the central nervous system.

Pharmacology

PD-128,907 exhibits high affinity and selectivity for D2-like dopamine receptors. It has been shown to have a higher affinity for the D3 receptor compared to the D2 and D4 receptors. This property is particularly useful in research focused on the D3 receptor, which is implicated in various neuropsychiatric disorders, including schizophrenia, Parkinson's disease, and drug addiction.

Research Applications

PD-128,907 is widely used in preclinical studies to investigate the role of D2-like dopamine receptors in behavior and neurochemistry. It has been employed in animal models to study:

• The effects of dopamine receptor activation on motor function and locomotion.
• The role of D2-like receptors in reward pathways and addiction.
• The involvement of these receptors in cognitive function and memory.

Potential Therapeutic Uses

While PD-128,907 is primarily a research tool, its selective action on D2-like receptors suggests potential therapeutic applications. For instance, D3 receptor agonists are being explored for their potential to treat drug addiction and cognitive deficits associated with schizophrenia and other neuropsychiatric conditions.

Safety and Toxicology

As with many research chemicals, the safety profile of PD-128,907 in humans is not well-established. It is primarily used in controlled laboratory settings, and its effects in humans have not been extensively studied.

See Also

• Dopamine receptor
• D2 receptor
• D3 receptor
• D4 receptor
• Schizophrenia
• Parkinson's disease
• Drug addiction

References

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