Pancreatic enzymes (medication)

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Pancreatic enzymes are medications that contain a mixture of digestive enzymes including amylase, lipase, and protease. These enzymes are essential for the digestion of carbohydrates, fats, and proteins, respectively. Pancreatic enzyme replacement therapy (PERT) is commonly used to treat conditions where the pancreas does not produce enough enzymes, such as pancreatitis, cystic fibrosis, and pancreatic cancer.

Mechanism of Action[edit | edit source]

Pancreatic enzymes work by supplementing the body's natural digestive enzymes. When taken with meals, they help break down food into smaller, absorbable nutrients. This is particularly important for individuals with exocrine pancreatic insufficiency (EPI), where the pancreas fails to secrete sufficient digestive enzymes.

Indications[edit | edit source]

Pancreatic enzyme medications are indicated for:

Chronic pancreatitis
Cystic fibrosis
Pancreatic cancer
Post-surgical conditions affecting the pancreas
Exocrine pancreatic insufficiency

Administration[edit | edit source]

Pancreatic enzymes are typically administered orally in the form of capsules or tablets. They should be taken with meals or snacks to ensure that the enzymes mix with food in the stomach and small intestine. Dosage is individualized based on the severity of enzyme deficiency and the fat content of the diet.

Side Effects[edit | edit source]

Common side effects of pancreatic enzyme medications include:

Rare but serious side effects can include:

Allergic reactions
Fibrosing colonopathy (in high doses)

Monitoring and Adjustments[edit | edit source]

Patients on pancreatic enzyme therapy should be regularly monitored to ensure the effectiveness of the treatment and to adjust dosages as necessary. Monitoring may include: