Pramocaine
Pramocaine (also known as proparacaine) is a local anesthetic of the amino ester group that is primarily used in topical ointic and ophthalmic preparations. It is also used in some surgical procedures.
History[edit | edit source]
Pramocaine was first synthesized in the mid-20th century and has been in use as a local anesthetic since then. It is a derivative of para-aminobenzoic acid (PABA).
Pharmacology[edit | edit source]
Pramocaine works by inhibiting sodium ion channels on the nerve cell membrane, preventing the propagation of action potentials and thus blocking the transmission of pain signals. It is a relatively weak anesthetic and has a short duration of action.
Uses[edit | edit source]
Pramocaine is primarily used in topical ointic and ophthalmic preparations. It is also used in some surgical procedures, particularly in ophthalmology, for local anesthesia.
Side Effects[edit | edit source]
Possible side effects of pramocaine include allergic reactions, skin irritation, and systemic toxicity if absorbed in large amounts.
Contraindications[edit | edit source]
Pramocaine is contraindicated in patients with a known hypersensitivity to it or to any other ester-type local anesthetic. It should also be used with caution in patients with impaired cardiovascular function.
See Also[edit | edit source]
References[edit | edit source]
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