Propiram

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Propiram is a synthetic opioid analgesic that was developed in the 1960s. It is chemically related to methadone and is used for the treatment of moderate to severe pain. Propiram is known for its analgesic properties and is classified as a Schedule IV controlled substance in the United States.

Pharmacology

Propiram acts as a partial agonist at the mu-opioid receptor and has some activity at the kappa-opioid receptor. Its analgesic effects are primarily due to its action on the mu-opioid receptor, which is responsible for pain relief. Unlike some other opioids, propiram has a lower potential for abuse and dependence.

Medical Use

Propiram is used in the management of moderate to severe pain. It is often prescribed when other pain relievers, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen, are not effective. Propiram can be administered orally or via injection.

Side Effects

Common side effects of propiram include:

• Nausea
• Vomiting
• Dizziness
• Constipation
• Sedation

Serious side effects may include respiratory depression, hypotension, and allergic reactions. It is important to use propiram under the supervision of a healthcare provider to minimize the risk of adverse effects.

Contraindications

Propiram should not be used in individuals with a history of opioid addiction, severe respiratory disorders, or hypersensitivity to the drug. It is also contraindicated in patients with acute or severe bronchial asthma.

Legal Status

In the United States, propiram is classified as a Schedule IV controlled substance under the Controlled Substances Act. This classification indicates that it has a lower potential for abuse compared to Schedule II or III substances but can still lead to physical or psychological dependence.

See Also

• Opioid
• Analgesic
• Methadone
• Pain management

External Links

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