Pulmonary venoocclusive disease

Pulmonary veno-occlusive disease (3627471184)

Pulmonary venoocclusive disease (PVOD) is a rare form of pulmonary hypertension characterized by the obstruction of the small pulmonary veins in the lungs. This condition leads to increased pressure in the pulmonary circulation, which can result in severe respiratory symptoms and heart failure.

Pathophysiology[edit | edit source]

PVOD is caused by the progressive blockage of the small pulmonary veins by fibrous tissue. This obstruction impedes the normal flow of blood through the lungs, leading to increased pressure in the pulmonary arteries. Over time, this increased pressure can cause damage to the right ventricle of the heart, as it works harder to pump blood through the narrowed vessels.

Symptoms[edit | edit source]

The symptoms of PVOD are similar to those of other forms of pulmonary hypertension and may include:

Dyspnea (shortness of breath)
Fatigue
Chest pain
Cyanosis (bluish discoloration of the skin)
Edema (swelling) in the legs and ankles
Syncope (fainting)

Diagnosis[edit | edit source]

Diagnosing PVOD can be challenging due to its similarity to other types of pulmonary hypertension. Diagnostic methods may include:

Echocardiography
Right heart catheterization
High-resolution computed tomography (HRCT) of the chest
Lung biopsy

Treatment[edit | edit source]

There is no cure for PVOD, and treatment primarily focuses on managing symptoms and improving quality of life. Treatment options may include:

Prognosis[edit | edit source]

The prognosis for individuals with PVOD is generally poor, with a median survival time of 2-3 years after diagnosis. Early detection and management are crucial for improving outcomes.