RBM15
RBM15 (RNA Binding Motif Protein 15) is a protein that in humans is encoded by the RBM15 gene. It is a member of the Splicing factor family of proteins, which play a crucial role in RNA splicing, a key process in gene expression.
Function[edit | edit source]
RBM15 is involved in the regulation of alternative splicing and influences the splice site selection by binding to specific RNA sequences. It also plays a role in the process of X-chromosome inactivation in female mammals, which is a crucial aspect of Sexual differentiation.
Clinical significance[edit | edit source]
Mutations in the RBM15 gene have been associated with various diseases. For instance, a specific translocation involving the RBM15 gene is associated with Acute megakaryoblastic leukemia, a subtype of Acute myeloid leukemia.
Interactions[edit | edit source]
RBM15 has been shown to interact with various other proteins, such as OTT1, SAP18, and SIN3A, which are involved in the regulation of gene expression and RNA splicing.
See also[edit | edit source]
- RNA-binding protein
- Splicing factor
- Gene expression
- Alternative splicing
- X-chromosome inactivation
- Sexual differentiation
- Acute megakaryoblastic leukemia
- Acute myeloid leukemia
References[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD