Rhogam

What is RhoGAM?[edit | edit source]

What are the uses of this medicine?[edit | edit source]

This medication is indicated for use in preventing Rh immunization for pregnancy and other obstetrical conditions in Rh-negative women and in any Rh-negative person after incompatible transfusion of Rh-positive blood.

How does this medicine work?[edit | edit source]

RhoGAM and MICRhoGAM act by supressing the immune response of Rh-negative individuals to Rh-positive red blood cells.
These products are not effective in altering the course or consequences of Rh immunization once it has occurred.

Who should not use this medicine?[edit | edit source]

This medicine cannot be used for:

Rh-positive individuals
patients with a known history of anaphylactic or severe systemic reactions to administration of human globulin products.

Is this medicine FDA approved?[edit | edit source]

RhoGAM was approved for use in the United States in 1968.

How should this medicine be administered?[edit | edit source]

RhoGAM and MICRhoGAM should be for intramuscular use only.
RhoGAM should be administered within 72 hours of delivery postpartum if the newborn is Rh-positive. It can also be administered antepartum within 72 hours of suspected or proven exposure to Rh-positive red blood cells.
MICRhoGAM should be administered within 72 hours if there is an actual or threatened termination of pregnancy up to and including 12 weeks gestation.
RhoGAM may be administered if MICRhoGAM is not available.

What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in the following dosage forms:

MICRhoGAM Ultra-Filtered PLUS - 50 μg (250 IU) Dose
RhoGAM Ultra-Filtered PLUS - 300 μg (1500 IU) Dose

What side effects can this medication cause?[edit | edit source]

Common possible side effects of this medicine include local reactions such as:

swelling
slight elevation in temperature
induration
redness and mild pain at the site of injection

What special precautions should I follow?[edit | edit source]

Severe hypersensitivity reactions may occur with the use of RhoGAM and MICRhoGAM.
RhoGAM and MICRhoGAM should be administered in a setting where appropriate equipment, medications such as epinephrine, and personnel trained in the management of hypersensitivity, anaphylaxis, and shock are available.
Patients treated for Rh-incompatible transfusion should be monitored by clinical and laboratory means for signs and symptoms of a hemolytic reaction.

What to do in case of emergency/overdose?[edit | edit source]

There are no reports of known overdoses in patients treated with RhoGAM.

Can this medicine be used in pregnancy?[edit | edit source]

RhoGAM is used in pregnant women for the supression of Rh isoimmunization. This medication does not harm the fetus or affect reproduction capacity.

Can this medicine be used in children?[edit | edit source]

The safety and effectiveness of RhoGAM in pediatric patients have not been established.

What should I know about storage of this medication? [edit | edit source]

Store at 2 to 8°C. Do not store frozen.
Do not use after the expiration date printed on the syringe.

Rhogam Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.