Sirtuin 1
Sirtuin 1 (also known as SIRT1) is a protein that in humans is encoded by the SIRT1 gene. It is a member of the sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT1 is known to regulate important biological pathways in bacteria, archaea, and eukaryotes.
Function[edit | edit source]
SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity). The complex formed by SIRT1 and its cofactor NAD+ (nicotinamide adenine dinucleotide) catalyzes the deacetylation of many important biological molecules.
Role in Disease and Aging[edit | edit source]
SIRT1 has been implicated in a variety of diseases, including cancer, diabetes, and neurodegenerative diseases. It has also been suggested to play a role in the aging process, with studies showing that increased SIRT1 activity can extend the lifespan of yeast, worms, and flies.
Research[edit | edit source]
Research into SIRT1 has been extensive, with studies investigating its role in disease and aging, as well as its potential as a therapeutic target.
See Also[edit | edit source]
References[edit | edit source]
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