Valproate sodium

Valproate Sodium is a medication primarily used to treat epilepsy and bipolar disorder. It is also used to prevent migraine headaches. It is available in oral and intravenous formulations.

Pharmacology

Valproate Sodium is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid (GABA) levels in the brain or by altering the properties of voltage dependent sodium channels.

Medical Uses

Valproate Sodium is used primarily to treat epilepsy and psychiatric conditions. It is among the most commonly used medications for these conditions. It is also used to prevent migraine headaches.

Epilepsy

Valproate Sodium is used to control certain types of seizures in the treatment of epilepsy. It can be used alone or in combination with other antiepileptic drugs.

Bipolar Disorder

Valproate Sodium is used in the treatment of the manic phase of bipolar disorder, where it can be used alone or in combination with other mood stabilizers.

Migraine

Valproate Sodium is also used to prevent migraine headaches. However, it is not used to relieve an active migraine headache.

Side Effects

Common side effects of Valproate Sodium include nausea, vomiting, dizziness, and tremor. Serious side effects can include liver problems, pancreatitis, and an increased risk of suicidal thoughts and behavior.

Contraindications

Valproate Sodium is contraindicated in people with liver disease, mitochondrial disease, and known hypersensitivity to the drug.

Interactions

Valproate Sodium can interact with a number of other medications, including other antiepileptic drugs, certain antidepressants, and certain antibiotics.

See Also

• Antiepileptic drugs
• Bipolar disorder
• Migraine

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