COX-2 inhibitors

<languages /><translate> Abbreviation for cyclooxygenase-2 inhibitors, medications that reduce pain and swelling by targeting a particular enzyme known as cyclooxygenase-2 (COX-2).

Anitrazafen structure - Cox-2 inhibitor.

• COX-2 inhibitors include drugs such as celecoxib (Celebrex) and rofecoxib (Vioxx).
• Although rofecoxib was withdrawn from the market in late 2004 due to adverse side effects associated with coronary problems, celecoxib remains on the market and is widely prescribed.
• COX-2 inhibitors are reported to induce fewer adverse gastrointestinal side effects compared with other traditional NSAIDs such as ibuprofen and naproxen.
• As a class, NSAIDs are used to treat pain and are commonly prescribed for treatment of arthritis.

Anti-inflammatory actions

Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) have anti­inflammatory, analgesic and antipyretic effects.

Mechanism of action

These medications work as inhibitors of the cyclo-oxygenase isoenzymes COX-1 or COX-2.

What are COX-1 and COX-2?

The enzyme cyclooxygenase 1 and cyclooxygenase 2 are involved in the production of prostaglandins and thromboxanes

Less GI side effects

Gastrointestinal (GI) side effects occur commonly with all NSAIDs. These events are mediated by inhibition of COX-1, responsible for synthesis of the prostaglandins that inhibit acid secretion. COX-2 selectivity reduces the risk of GI adverse events

Cross reactivity between COX-1 and COX-2

• COX-2 inhibitors still have a low affinity for COX-1.

How to reduce risk of GI bleeds?

• Using the lowest effective dose
• Shortest duration possible.
• Avoiding the concomitant use of more than one NSAID
• Avoiding the concomitant use of aspirin a
• Avoid use anticoagulant where possible
• Consider use of proton pump inhibitor.

Celecoxib-3D-balls

List of COX-2 inhibitors

• Anitrazafen

• Apricoxib

• Celecoxib

• Cimicoxib

• Deracoxib

• Etoricoxib

• Firocoxib

• Flumizole

• Lumiracoxib

• Mavacoxib

• Pamicogrel

• Parecoxib

• Polmacoxib

• Robenacoxib

• Rofecoxib

• Rutecarpine

• Tilmacoxib

• Valdecoxib

• Zaltoprofen

COX-2 inhibitors Resources
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