Cathepsin

Cathepsin is a type of protein that acts as a protease, a type of enzyme that breaks down proteins. There are several types of cathepsins, including cathepsin B, D, and L. These proteins are found in all animals and other organisms, and they play a key role in cellular protein turnover. The term "cathepsin" comes from the Greek word for "to digest."

Function

Cathepsins have a vital role in protein degradation, apoptosis, and tissue remodeling. They are primarily located in the lysosome, an organelle in the cell that digests waste materials and cellular debris. Cathepsins have the ability to break down proteins into their constituent amino acids, which can then be reused by the cell.

Types

There are several types of cathepsins, each with its own specific function. These include:

• Cathepsin B: This enzyme can break down proteins and peptides. It is involved in the process of inflammation and has been linked to the development of cancer.
• Cathepsin D: This enzyme is involved in protein degradation and is important for the normal functioning of cells. It has been associated with breast cancer and Alzheimer's disease.
• Cathepsin L: This enzyme is involved in the process of autophagy, the breakdown and recycling of cellular components. It has been linked to diseases such as cancer and rheumatoid arthritis.

Clinical significance

Abnormal levels of cathepsins have been linked to a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. For example, overexpression of cathepsin B has been observed in many types of cancer, and it is thought to contribute to tumor progression. Similarly, cathepsin D has been implicated in the development of Alzheimer's disease.

See also

• Protease
• Lysosome
• Protein degradation
• Apoptosis
• Tissue remodeling

References

Cathepsin Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski