Extended-release

Extended-release is a term in pharmacology that describes the process by which a drug is released in a controlled manner, not immediately, after its administration. Extended-release mechanisms are designed to prolong the effect of a drug so it can be given less often.

Mechanism of Action

The mechanism of action of extended-release medications involves the slow release of the active ingredient over time. This is achieved through various formulation strategies such as coating the drug with a material that dissolves slowly, or embedding the drug in a matrix that gradually breaks down.

Advantages

The main advantage of extended-release formulations is that they can maintain a steady level of the drug in the body for a longer period of time. This can improve the efficacy of the drug and reduce the frequency of dosing, which can improve patient compliance.

Disadvantages

However, extended-release formulations also have some disadvantages. They can be more expensive to produce and may not be suitable for all drugs or all patients. For example, they may not be appropriate for drugs that need to be absorbed quickly, or for patients who have difficulty swallowing pills.

Examples

Some examples of extended-release medications include certain forms of metformin, a drug used to treat type 2 diabetes, and bupropion, an antidepressant.

See Also

• Immediate release
• Controlled release
• Drug delivery systems

Extended-release Resources
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