Factor v leiden

Factor V Leiden is a mutation of one of the clotting factors in the blood called factor V. This mutation can increase your chance of developing abnormal blood clots (thrombophilia), which can lead to conditions such as deep vein thrombosis or pulmonary embolism.

Overview

Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots in blood vessels. People who have the Factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in veins, such as the deep veins of the legs (deep venous thrombosis, or DVT).

Causes

The Factor V Leiden mutation is passed down through families in an autosomal dominant manner. This means that if one of your parents has the mutation, you have a 50 percent chance of inheriting it. The mutation is in the factor V gene, which is involved in blood clotting.

Symptoms

Most people with the Factor V Leiden mutation never develop abnormal clots. However, some people with this mutation are at an increased risk of developing clots, especially if they have other risk factors such as prolonged bed rest, pregnancy, or use of birth control pills.

Diagnosis

The diagnosis of Factor V Leiden thrombophilia is suggested by the personal and family history and confirmed by specific blood tests.

Treatment

The treatment of Factor V Leiden thrombophilia is aimed at preventing the initial occurrence or recurrence of venous thromboembolism. This is often done with the use of anticoagulant medications.

See Also

• Thrombophilia
• Deep vein thrombosis
• Pulmonary embolism
• Factor V

Factor v leiden Resources
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